Immunologic measurement of polycyclic aromatic hydrocarbon-albumin adducts in foundry workers and roofers.
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چکیده
منابع مشابه
Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells and urinary 1-hydroxypyrene in foundry workers.
In an ongoing comprehensive evaluation of biological markers, workers in or near an iron foundry with varying exposure to polycyclic aromatic hydrocarbons (PAH) were analyzed for molecular response to this exposure. Exposure to benzo(a)pyrene, determined by personal monitors worn by the workers (2 to 60 ng/m3), was considerably lower than in a previous study at this foundry (< 50 to 200 ng/m3) ...
متن کاملDetection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers.
Iron foundry workers, exposed to high levels of polycyclic aromatic hydrocarbons (PAHs), silica, and metal fumes and dusts, are at elevated risk of lung cancer. Benzo(a)pyrene and a number of structurally related PAHs are metabolically activated to diol epoxides (e.g., 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a) pyrene) which are mutagenic, carcinogenic in experi...
متن کاملDetection of Polycyclic Aromatic Hydrocarbon-DNA Adducts in White Blood Cells of Foundry Workers1
Iron foundry workers, exposed to high levels of polycyclic aromatic hydrocarbons (PAHs), silica, and metal fumes and dusts, are at elevated risk of lung cancer. Benzo(a)pyrene and a number of structurally related PAHs are metabolically activated to diol epoxides (e.g., 7/S,8a-dihydroxy9a,10a-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene) which are mutagenic, carcinogenic in experimental animals, and ...
متن کاملDetection of polycyclic aromatic hydrocarbon-DNA adducts in human lung.
Molecular dosimetry for polycyclic aromatic hydrocarbon-DNA adducts, genetic predisposition to cancer, and their interrelationships are under study in numerous laboratories. This report describes a modified 32P-postlabeling assay for the detection of polycyclic aromatic hydrocarbon-DNA adducts that uses immunoaffinity chromatography to enhance chemical specificity and quantitative reliability. ...
متن کاملDeterminants of polycyclic aromatic hydrocarbon-DNA adducts in human placenta.
To determine the relative contributions of tobacco smoking and P-450 metabolism (cytochrome P-450IAI) in the formation of benzo(a)pyrenediol-epoxide and other polycyclic aromatic hydrocarbon-DNA adducts in vivo, 16 human placentas were assayed for aryl hydrocarbon hydroxylase activity and (+/-)r-7,t-8-dihydroxy-c-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene-DN A adduct levels. Immunoaffinity ch...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Work, Environment & Health
سال: 1991
ISSN: 0355-3140,1795-990X
DOI: 10.5271/sjweh.1711